HRA members learned about preregistering research at the Fall 2017 HRA Members Meeting in Chicago in a session entitled “Open Science – Pre-registration: Approaches to ensuring reproducibility and transparency.” Reproducibility and transparency are critical elements to advancing biomedical research while providing scientists a tool for the future to better understand their data and outcomes. The use of pre-registration and the strengths and challenges for funders to incorporate pre-registration as part of evaluation metrics were presented in this session. Perspectives for both non-clinical and clinical data were presented to show how pre-registration may be a useful resource to ensure that funded... read more →
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If you are not happy with the results below please do another searchDr. Brian Nosek, Executive Director, Center for Open Science Fall 2015 HRA Members Meeting, Cleveland, OH An academic scientist’s professional success depends on publishing. Publishing norms emphasize novel, positive results. Therefore, disciplinary incentives encourage design, analysis, and reporting decisions that elicit positive results and ignore negative results. These incentives can inflate the rate of false effects in published science. Indeed, several recent papers have reported a frequent lack of reproducibility in published biomedical science. In order to fully assess the extent of this problem and identify best practices that maximize reproducibility, “The Reproducibility Project: Cancer Biology” was developed. This project... read more →
Open Science is the principle and practice of making research products and processes available to all, which fosters collaborations, reproducibility, and equity. This session will explore the ways in which funders can implement open policies that complement those of federal agencies. The session opened with an overview of current federal requirements related to open science including guidance from the Office of Science and Technology Policy to make federally funded research freely available without delay. In the second part of the session, we heard from the Open Science Learning Community and learn more about the HRA community's needs as it pertains... read more →
Tracking Researchers Public Access Post-Award: Funded researchers are required to submit, or have submitted for them, to the National Institutes of Health’s Pub Med Central database an electronic version of the author’s final manuscript including all modifications resulting from the publishing and peer review process (the “postprint”) upon acceptance for publication, to be made publicly available no later than 12 months after the official date of publication. This requirement applies to all publications related to funded research grants whether the research was funded in whole or in part. All scientific progress reports must include the PMC ID number (PMCnnnnn) for... read more →
By conducting peer review prior to data collection, Registered Reports publications emphasize the importance of the research question and the quality of methodology rather than the results of a study. Funders have adopted the Registered Reports format to increase the quality of funded studies to a ‘publication-ready’ peer review journal level, and to enable publication of ‘negative’ results, which can be just as important as ‘positive’ results. Publishers are adopting Registered Reports to incentivize pre-registration and reproducibility and increase scientific rigor. Researchers benefit from increased quality of studies, a clear publication path, and more transparent research. Funders’ Perspectives: Salvatore La Rosa... read more →
The open access protocols.io platform makes it easy to share research recipes and to collaborate on method development, both publicly and privately. This free platform addresses lack of reproducibility due to less than helpful materials and methods sections containing instructions like "we used a modified version of a protocol reported previously" or "contact author for details". Lenny Teytelman is the CEO, and Cofounder of protocols.io, and will describe the platform and how can not only improve your grantees’ research workflow but also enhance rigor and reproducibility. We will also hear from Jonah Cool a science program officer at the Chan Zuckerberg Initiative. CZI is a major... read more →
Scientific peer review has long been the gold standard for evaluating grant applications, but different organizations implement peer review in different ways. In addition, issues like unconscious bias and data reproducibility has brought these processes under greater scrutiny. This session will focus on peer review best practices that are informed by studies on the science of peer review. Moderator Diane Bovenkamp, PhD Vice President of Scientific Affairs | BrightFocus Foundation Presenters Stephen Gallo, PhD (Presentation) Chief Scientist | American Institute of Biological Sciences Lucy Liaw, PhD (Presentation) Director, Research Training Programs | Maine Medical Center Research Institute Richard Nakamura, PhD (Presentation) Former Director... read more →
Under development by the Drug and Other Therapy Development working group, this “toolkit of toolkits” will enable member organizations to more easily identify and access existing and up-to-date resources relevant to DOTD working group goals. Drug and Other Therapy Development References U.S. Food and Drug Administration - for the latest developments in regulatory policies and regulatory science. National Institute of Neurological Disorders and Stroke - resources and tools needed to advance the fundamental knowledge about the brain and nervous system and to use that knowledge to reduce the burden of neurological disease. QB3 - hub for innovation and entrepreneurship in the life sciences: a... read more →
One of the most valuable resources for HRA and others in the community has been the FAIR Guiding Principles for Scientific Data Management and Stewardship published in Nature. This article describes four foundational principles—Findability, Accessibility, Interoperability, and Reusability. These principles should apply not only to ‘data’ but also to the code, tools, and workflows that led to that data. According to the authors, “all scholarly digital research objects—from data to analytical pipelines—benefit from application of these principles, since all components of the research process must be available to ensure transparency, reproducibility, and reusability.” To further ensure HRA members are aware... read more →
A partnership between HRA and Center for Open Science designed to increase openness, integrity, and reproducibility of research HRA partnered with the Center for Open Science to co-host a December 2016 meeting: Maximizing Research Impact: How Promoting Open and Reproducible Research Helps Funding Organizations Meet Their Mission. The linked Open Science Framework project contains supporting materials for that meeting. Among the highlights from that effort were a few actions funders can do today to increase the impact of the work we support. Preprints Share the COS Preprints service with your organization and encourage your grantees to use this service Launch/support a... read more →